Deletions in (CCCT)n repeat regions belonging to the human pRNA gene inhibit its expression
These findings allowed us to establish directly the inhibitory effect of DNA variants on the expression of pRNA and thus (indirectly) the promoting effect on the production of ribosomal RNA. Our results also suggest that (CCCT)<sub>n</sub>/(GGGA)<sub>n</sub> DNA repeats and the respective (GGGA)<sub>n</sub> RNA repeats may form triplex structures, facilitating the function of pRNA.
Authors
- Evgeny Smirnov (ORCID: https://orcid.org/0000-0002-5465-3846)
- Nikola Chmúrčiaková (ORCID: https://orcid.org/0000-0003-4080-7557)
- Dušan Cmarko (ORCID: https://orcid.org/0000-0002-7467-8565)
- Adam Nógell (ORCID: https://orcid.org/0009-0003-7430-8024)
Institutions
- Charles University (CZ)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40246-025-00830-w
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Karlova v Praze