Ambient temperature modulates the effects of peripheral Y1R antagonism on diet-induced obesity and glucose intolerance
Peripheral Y1R blockade-induced reductions in body weight and enhancements in energy expenditure at room temperature are abolished under thermoneutrality, irrespective of dietary fat content.Glucose-lowering effects of peripheral Y1R antagonism persist under thermoneutrality, independent of changes in body weight and insulin sensitivity.Chronic thermoneutrality blunts the ability of peripheral Y1R blockade to ameliorate fat-induced glucose intoleranceThese findings emphasize the temperature-dependent efficacy of metabolic drugs and the need for climate-adjusted therapeutic strategies.
Authors
- Yan‐Chuan Shi (ORCID: https://orcid.org/0000-0002-8368-6735)
- Qi Wu (ORCID: https://orcid.org/0000-0003-3248-8322)
- Zhong‐Min Gao (ORCID: https://orcid.org/0000-0003-1079-9269)
- Gopana Gopalasingam
- Chenxu Yan (ORCID: https://orcid.org/0000-0001-7130-769X)
- Hanyu Gao (ORCID: https://orcid.org/0000-0002-6346-0739)
- Renjing Liu (ORCID: https://orcid.org/0000-0001-9099-0076)
- Chi Kin Ip (ORCID: https://orcid.org/0000-0002-0464-4706)
- Herbert Herzog
- D. Subbaram Naidu (ORCID: https://orcid.org/0009-0001-5111-5639)
Institutions
- Garvan Institute of Medical Research (AU)
- Victor Chang Cardiac Research Institute (AU)
- UNSW Sydney (AU)
- St Vincent's Clinic (AU)
- St Vincents Institute of Medical Research (AU)
Publication Details
- Journal
- Journal of Endocrinology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1530/joe-25-0233
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00