Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer
An automated method for the radiochemical synthesis of [<sup>18</sup>F]fluoromannitol was developed and optimized on a commercially available Trasis AllinOne radiosynthesizer. This method allows for the reliable production and global dissemination of [<sup>18</sup>F]FMtl for use in clinical research trials.
Authors
- Kiel D. Neumann (ORCID: https://orcid.org/0000-0001-9093-3522)
- Spenser R. Simpson
- Amy L. Vāvere (ORCID: https://orcid.org/0009-0008-2011-8790)
- Matthew S. Brown (ORCID: https://orcid.org/0000-0003-0575-3696)
- Allison J. Clay
- Arijit Ghosh (ORCID: https://orcid.org/0009-0007-8224-7734)
- Joana Marie Almazan
Institutions
- St. Jude Children's Research Hospital (US)
- Clinical Solutions (US)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s41181-025-00388-x
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- St. Jude Children's Research Hospital
- American Lebanese Syrian Associated Charities
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Biomedical Imaging and Bioengineering