Synthesis of Dihydroisoquinolone-Fused Cyclobutanes via Tandem Palladium-Mediated Olefin Migration and Photosensitized [2 + 2] Cycloaddition
A tandem palladium-mediated olefin migration and visible light-promoted [2 + 2] cycloaddition reaction was disclosed. It provides a facile method to synthesize the cyclobutane-fused dihydroisoquinolone-based polycycles bearing a methyl group. Further product derivatization enables the efficient construction of diverse cyclobutane derivatives. Mechanistic studies revealed that the palladium catalysts promoted the olefin migration and inhibited the direct [2 + 2] cyclization of substrates.
Authors
- Siping Wei (ORCID: https://orcid.org/0000-0002-1084-8772)
- Qiang Fu (ORCID: https://orcid.org/0000-0001-9993-8776)
- Yimou Gong (ORCID: https://orcid.org/0009-0006-8628-085X)
- Zhijie Zhang (ORCID: https://orcid.org/0000-0001-7793-2453)
- Xiong Cheng
- Zhen Xiang (ORCID: https://orcid.org/0000-0001-6184-9102)
- Jing Peng (ORCID: https://orcid.org/0000-0002-5232-6227)
- Chuan Feng
Institutions
- Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1021/acs.orglett.5c03602
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00