NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia
Our results demonstrate that NSUN2 facilitates leukemogenesis by increasing FTH1 expression and enhancing global protein synthesis in an m<sup>5</sup>C-dependent manner. Targeting NSUN2 might provide a promising therapeutic strategy for B-ALL.
Authors
- Yigang Yuan
- Chongyun Xing
- Xinyao Chen (ORCID: https://orcid.org/0000-0003-2421-1649)
- Meng Chen (ORCID: https://orcid.org/0000-0002-2581-6685)
- Shanhu Qian
- Ziyang Huang (ORCID: https://orcid.org/0000-0001-6422-225X)
- Liuzhi Shi (ORCID: https://orcid.org/0000-0001-9484-8616)
- Shenmeng Gao (ORCID: https://orcid.org/0000-0003-1223-4325)
- Xuzhen Qin (ORCID: https://orcid.org/0000-0003-3877-8021)
- Min Li (ORCID: https://orcid.org/0000-0002-3578-2239)
- Bin Zhou (ORCID: https://orcid.org/0000-0001-5278-5522)
- Shixin Zhang
- Xiaodong Yu
- Shirui Yu (ORCID: https://orcid.org/0009-0008-7914-9647)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13148-025-01994-x
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province