Inhibition of acn-1, an ACE ortholog, reduces intestinal GST-4 expression in Caenorhabditis elegans

We investigated the role of <i>acn-1</i> , the <i>C. elegans</i> ortholog of human ACE and ACE2, on the expression of GST-4 , an antioxidant molecule produced in response to oxidative stress. <i>acn-1</i> RNAi exposure significantly reduced GST-4 reporter expression after 24 and 48 hours. The difference in <i>gst-4</i> expression appears most prevalent in the intestine. Our findings suggest that <i>acn-1</i> function positively influences <i>gst-4</i> expression in <i>C. elegans</i> .