Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation
Our findings suggest that NR4A2 activation in ZG cells functions as a key molecular mediator in stress-induced APCC formation at least in some cases. Some APCCs maintained ZG-like characteristics with heightened stress responsiveness, representing a distinct cellular state from aldosterone-producing adenomas, which exhibit metabolic reprogramming and enhanced energy metabolism.
Authors
- Masatoshi Eto (ORCID: https://orcid.org/0000-0002-3312-9930)
- Hironobu Umakoshi (ORCID: https://orcid.org/0000-0003-4293-287X)
- Shohei Sakamoto
- Takamasa Ichijo (ORCID: https://orcid.org/0000-0002-2969-7396)
- Ryuichi Sakamoto (ORCID: https://orcid.org/0000-0002-8276-9678)
- T Watanabe (ORCID: https://orcid.org/0000-0002-6543-0437)
- Norio Wada
- Seishi Ogawa (ORCID: https://orcid.org/0000-0002-7778-5374)
- Masahide Seki (ORCID: https://orcid.org/0000-0001-6091-8698)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Tatsuki Ogasawara (ORCID: https://orcid.org/0000-0003-4766-7817)
- Yutaka Suzuki (ORCID: https://orcid.org/0000-0003-4852-1879)
- Yuya Kitamura (ORCID: https://orcid.org/0000-0001-7922-5074)
- Norifusa Iwahashi (ORCID: https://orcid.org/0000-0001-9881-9126)
- Hiroki Kaneko (ORCID: https://orcid.org/0000-0001-6998-1917)
- Maki Yokomoto‐Umakoshi (ORCID: https://orcid.org/0000-0003-0934-9148)
- Masamichi Fujita (ORCID: https://orcid.org/0009-0008-1316-1774)
- Yoshihiro Ogawa (ORCID: https://orcid.org/0000-0002-0834-2836)
- Koshiro Nishimoto (ORCID: https://orcid.org/0000-0002-3952-5643)
- Takashi Matsumoto (ORCID: https://orcid.org/0000-0003-2653-5372)
- Tazuru Fukumoto (ORCID: https://orcid.org/0009-0003-2870-2776)
Institutions
- University of Miyazaki (JP)
- Kyushu University (JP)
- Chiba University (JP)
- Kyoto University (JP)
- National Kyushu Medical Center (JP)
- Sapporo City General Hospital (JP)
Publication Details
- Journal
- Hypertension
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1161/hypertensionaha.125.24825
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00