Meeting Summary for Keystone Symposia on HIV Cure: Antiretroviral Therapy (ART)-Free Control of HIV Infection in Durban, South Africa, 2025
Antiretroviral therapy (ART) can effectively control human immunodeficiency virus (HIV) replication; however, lifelong treatment is required due to viral reservoirs, which fuel viral rebound. This necessitates curative interventions that can achieve either eradication of the reservoir or durable remission off ART. Advances in technology have fostered development of multi-omic techniques encompassing molecular tools, proteomic analyses, imaging, and artificial intelligence (AI)-driven data analysis to understand HIV reservoir biology and persistence. These have informed the investigation of therapeutic interventions such as broadly neutralizing antibodies, latency reversal, immune cell augmentation, antivirals, and gene therapy. From April 7-10, 2025, experts in the field convened at the Keystone Symposia conference, HIV Cure: Antiretroviral Therapy (ART)-Free Control of HIV Infection in Durban, South Africa, to discuss novel strategies for eradication and/or durable ART-free control of HIV.
Authors
- Kiho Tanaka
- Thomas A. Rasmussen (ORCID: https://orcid.org/0000-0001-5354-2442)
- Jacob D. Estes (ORCID: https://orcid.org/0000-0002-9652-6394)
- Chang Li (ORCID: https://orcid.org/0000-0002-3267-1859)
- Kavidha Reddy (ORCID: https://orcid.org/0000-0002-7024-0574)
- Ya‐Chi Ho (ORCID: https://orcid.org/0000-0002-7046-0147)
- Zaza M. Ndhlovu (ORCID: https://orcid.org/0000-0002-2708-3315)
- Sizun Jiang (ORCID: https://orcid.org/0000-0001-6149-3142)
- Thumbi Ndung’u (ORCID: https://orcid.org/0000-0003-2962-3992)
- Ujjwal Neogi (ORCID: https://orcid.org/0000-0002-0844-3338)
- Rachel L. Rutishauser (ORCID: https://orcid.org/0000-0003-3596-059X)
- James E. Voss (ORCID: https://orcid.org/0000-0002-4777-1596)
- Albert Machinda
- Sharon R. Lewin (ORCID: https://orcid.org/0000-0002-0330-8241)
- Mélanie Ott (ORCID: https://orcid.org/0000-0002-5697-1274)
- Joseph M. McCune (ORCID: https://orcid.org/0000-0002-9388-070X)
- Caroline T. Tiemessen (ORCID: https://orcid.org/0000-0002-0991-1690)
- Tatenda JB Chikowore
- Ming Lee (ORCID: https://orcid.org/0000-0002-5244-0070)
- Maurício Antônio Paz Martins (ORCID: https://orcid.org/0000-0002-1088-6074)
- Cissy Kityo
- Steven G Deeks
- Anna Farrell-Sherman
- Patrick Mdletshe
Institutions
- National Health Laboratory Service (ZA)
- Scripps Research Institute (US)
- Gates Foundation (US)
- Beth Israel Deaconess Medical Center (US)
- The Royal Melbourne Hospital (AU)
- Gladstone Institutes (US)
- Infectious Disease Research Institute (US)
- Oregon Health & Science University (US)
- The University of Melbourne (AU)
- University of California, San Francisco (US)
- University of Washington (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- University of Washington Medical Center (US)
- Aarhus University Hospital (DK)
- Ragon Institute of MGH, MIT and Harvard (US)
- Karolinska Institutet (SE)
- Yale University (US)
- Fred Hutch Cancer Center (US)
- Peter Doherty Institute (AU)
- Africa Health Research Institute (ZA)
- University of Africa (ZM)
- Joint Clinical Research Centre (UG)
- University College London (GB)
- Imperial College London (GB)
- Monash University (AU)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Pathogens and Immunity
- Published
- 2025-10-18
- DOI
- https://doi.org/10.20411/pai.v10i2.885
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation