Outcomes and Tolerability of Early Mammalian Target of Rapamycin Inhibitor Initiation for Renal Sparing in Heart Transplant Recipients

In our experience, early mTORi initiation was associated with renal benefits in HTRs when compared to SOC. Conversion to mTORi allowed for lower tacrolimus levels without an increased risk for rejection or DSAs and was associated with less cardiac allograft vasculopathy at 24 months.

Authors

Patricia P. Chang
Christina Teeter Doligalski
Ann C. Marcotte
Mirnela Byku (ORCID: https://orcid.org/0000-0002-4541-5053)
Rachel Rikard (ORCID: https://orcid.org/0000-0003-0670-6998)
C. William Castor
Margeaux Meilhac

Institutions

University of North Carolina at Chapel Hill (US)
University of North Carolina Health Care (US)

Publication Details

Journal: Clinical Transplantation
Published: 2025-10-27
DOI: https://doi.org/10.1111/ctr.70364
Primary Topic: Transplantation: Methods and Outcomes
Type: article
Field-Weighted Citation Impact: 0.00

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article

Outcomes and Tolerability of Early Mammalian Target of Rapamycin Inhibitor Initiation for Renal Sparing in Heart Transplant Recipients

Patricia P. Chang, Christina Teeter Doligalski, Ann C. Marcotte, Mirnela Byku et al.

Oct 27, 2025

Clinical Transplantation

Transplantation: Methods and Outcomes

article

Outcomes and Tolerability of Early Mammalian Target of Rapamycin Inhibitor Initiation for Renal Sparing in Heart Transplant Recipients

Patricia P. Chang, Christina Teeter Doligalski, Ann C. Marcotte, Mirnela Byku, Rachel Rikard, C. William Castor, Margeaux Meilhac

October 27, 2025article en

Abstract

In our experience, early mTORi initiation was associated with renal benefits in HTRs when compared to SOC. Conversion to mTORi allowed for lower tacrolimus levels without an increased risk for rejection or DSAs and was associated with less cardiac allograft vasculopathy at 24 months.

Clinical TransplantationVol. 39(11)

University of North Carolina at Chapel Hill (US), University of North Carolina Health Care (US)

Openalex Percentile: Top 51%

Transplantation: Methods and Outcomes

DOI Source OpenAlex

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