Synthesis of the decalin structure of cladoic acid
The intramolecular Diels-Alder reaction was employed for the assembly of the trans-decalin structure of cladoic acid, an anti-Trypanosoma cruzi active polyketide isolated from a fungus of the genus Cladosporium. Although the cycloaddition provided the desired trans-octalin as a minor product, the method was effective for simultaneously constructing four stereocenters in the B-ring of cladoic acid.
Authors
- Issey Osaka (ORCID: https://orcid.org/0000-0002-3642-2278)
- Keisuke Fukaya (ORCID: https://orcid.org/0000-0002-7148-4714)
- Daisuke Urabe (ORCID: https://orcid.org/0000-0002-1999-9374)
- Taisei Matoba
- Md. Masud Rana (ORCID: https://orcid.org/0000-0002-0550-7850)
- Chouma Kurihashi
- Azumi Kasashima
Institutions
- Toyama Prefectural University (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1093/bbb/zbaf154
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00