Atypical presentation of Adult T-Cell Leukemia/Lymphoma in a United States Veteran exposed to Human T-lymphotropic virus type-1.
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive peripheral T-lymphocytic malignancy of mature CD4+ T-cells caused by the retrovirus human T-lymphotropic virus-1 (HTLV-1) infection endemic to Japan, Africa, the Caribbean, and South America.1 ATLL is not commonly encountered in the United States as the US HTLV-1 seroprevalence is 5.1 per 100 000.2 Therefore, a targeted approach to screen certain populations at risk to HTLV-1 exposure, such as US veterans, travelers, or immigrants, is warranted when considering ATLL diagnosis.
Authors
- Jason B. Lee (ORCID: https://orcid.org/0000-0002-6399-2719)
- Pierluigi Porcu (ORCID: https://orcid.org/0000-0002-8056-023X)
- Laura Gleason (ORCID: https://orcid.org/0000-0003-3507-2728)
- Molly Wallace (ORCID: https://orcid.org/0009-0002-8517-0481)
- Neda Nikbakht (ORCID: https://orcid.org/0000-0002-9587-8689)
- Safiyyah Bhatti (ORCID: https://orcid.org/0009-0000-0267-1607)
- Trinh Duong (ORCID: https://orcid.org/0009-0003-1052-0827)
Institutions
- Thomas Jefferson University (US)
Publication Details
- Journal
- JAAD Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jdcr.2025.08.044
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00