in vitro antibacterial activity of nordihydroguaiaretic acid combined with ceftriaxone against carbapenem-resistant Klebsiella pneumoniae
Efflux pumps and biofilms synergistically enhance CRKP resistance. By inhibiting both efflux-mediated antibiotic extrusion and biofilm formation, NDGA resensitizes CRKP to CRO. This in vitro efficacy supports further development, pending in vivo safety studies in animal models.
Authors
- Cheng Luo (ORCID: https://orcid.org/0000-0003-0524-5886)
- Hang Sun (ORCID: https://orcid.org/0009-0003-8554-0152)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1810-8250)
- Xianwei Zhang (ORCID: https://orcid.org/0000-0001-9361-8202)
- Tan Hua
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.jgar.2025.10.007
- Citations
- 1
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.81