Inhibition of NCOA4/FTH1-mediated ferritinophagy attenuates ferroptosis in PDLCs and alleviates orthodontically induced inflammatory root resorption
NCOA4/FTH1-mediated ferritinophagy promotes ferroptosis under compressive and inflammatory conditions, contributing to OIIRR pathogenesis. Targeting the NCOA4/FTH1 axis may represent a promising therapeutic strategy for preventing orthodontically induced root resorption.
Authors
- Runze Zhang
- Chunmiao Jiang (ORCID: https://orcid.org/0000-0002-9571-0958)
- Hong Ding (ORCID: https://orcid.org/0000-0002-9998-0904)
- Xueyuan Han (ORCID: https://orcid.org/0000-0002-9784-946X)
- Zhe Zhou (ORCID: https://orcid.org/0009-0006-6451-9719)
- Dongyang Li (ORCID: https://orcid.org/0000-0003-1559-2785)
- Kexin Huang (ORCID: https://orcid.org/0009-0003-5576-2213)
- Liyan Liu
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Progress in Orthodontics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40510-025-00590-2
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Natural Science Foundation of Shandong Province