Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer’s disease pathology and cognitive decline
This study extends prior work by translating brain 5hmC profiles into epigenetic scores that distinguish AD pathology and reflect individual cognitive trajectories. These findings highlight the potential of brain-derived 5hmC modifications as biomarkers for AD and as tools to advance research on disease progression, offering a new direction for epigenetics-informed clinical applications in AD.
Authors
- Xiaolong Cui (ORCID: https://orcid.org/0000-0002-1345-2271)
- Shinya Tasaki (ORCID: https://orcid.org/0000-0003-3656-7394)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Alana V. Beadell (ORCID: https://orcid.org/0000-0001-6245-1649)
- Rupal I. Mehta (ORCID: https://orcid.org/0000-0003-4917-6907)
- Chuan He (ORCID: https://orcid.org/0000-0003-4319-7424)
- Zhou Zhang (ORCID: https://orcid.org/0000-0002-9639-052X)
- Wei Zhang (ORCID: https://orcid.org/0009-0004-4280-7563)
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- University of Chicago (US)
- Rush University (US)
Publication Details
- Journal
- Acta Neuropathologica
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1007/s00401-025-02950-y
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00