METTL1-mediated m7G modification regulates osteogenic differentiation of human periodontal ligament stem cells
METTL1 promotes osteogenic differentiation in PDLSCs through m7G modification-mediated stabilization of RUNX2 expression. This discovery unveils a novel epigenetic regulatory mechanism involving m7G modification in periodontal tissue regeneration, offering potential therapeutic targets for bone defect repair applications.
Authors
- Kunlun Li (ORCID: https://orcid.org/0009-0006-0300-5845)
- A. S. H. Wu (ORCID: https://orcid.org/0009-0001-8992-3447)
- Chungang Zhao (ORCID: https://orcid.org/0009-0006-2805-5363)
Institutions
- First People’s Hospital of Jingmen (CN)
- Jingchu University of Technology (CN)
Publication Details
- Journal
- Clinics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.clinsp.2025.100813
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00