Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory‐Related Lipid Transfer Domain‐3‐Voltage‐Dependent Anion Channel 1 Axis and Inositol 1,4,5‐Trisphosphate Receptor T
Our findings demonstrate that NPC1 downregulation represents a novel mechanism driving elevated aldosterone production, linking lysosomal-mitochondria cholesterol transport to aldosterone high production. These results suggest that NPC1 may offer a new understanding for aldosterone overproduction mechanism of aldosterone-producing adenomas.
Authors
- Chuan Peng (ORCID: https://orcid.org/0009-0009-5495-3732)
- Rufei Gao (ORCID: https://orcid.org/0000-0003-1409-4995)
- Jinbo Hu (ORCID: https://orcid.org/0000-0003-2925-0583)
- Weihua Li (ORCID: https://orcid.org/0000-0001-9215-4979)
- Wei Huang (ORCID: https://orcid.org/0000-0001-8279-6345)
- Yong Xu (ORCID: https://orcid.org/0000-0002-9534-6252)
- Linqiang Ma (ORCID: https://orcid.org/0009-0009-9503-0985)
- Jun Chen (ORCID: https://orcid.org/0000-0002-4059-3512)
- Shumin Yang (ORCID: https://orcid.org/0000-0002-0238-4779)
- Hongji Li (ORCID: https://orcid.org/0009-0007-8769-8788)
- Qifu Li (ORCID: https://orcid.org/0000-0001-7249-6445)
- Zhipeng Wu (ORCID: https://orcid.org/0000-0002-9682-6565)
- Miaoyun Chen
- Furong He
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1161/jaha.125.045554
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00