Circulating Cathepsin D Exacerbates Injury‐Induced Brain Damage by Promoting Neutrophil Infiltration Into the Brain
Taken together, these results demonstrate that circulating prototype CTSD exacerbates the injury-induced brain damage by upregulating brain endothelial VCAM-1 and promoting neutrophil transmigration into the brain.
Authors
- Qinghua Gao (ORCID: https://orcid.org/0000-0002-4362-2817)
- Jia Xing (ORCID: https://orcid.org/0000-0001-7521-9806)
- X Y Zhang
- Yanfang Liang (ORCID: https://orcid.org/0009-0006-6521-452X)
- Xue Sun (ORCID: https://orcid.org/0009-0001-9384-8013)
- Li Tian
- Hongzan Sun (ORCID: https://orcid.org/0000-0002-4724-5828)
- Ming‐Xin An (ORCID: https://orcid.org/0009-0007-2730-4484)
- Wei‐Dong Zhao (ORCID: https://orcid.org/0000-0003-0029-4400)
- Dan Zhao (ORCID: https://orcid.org/0000-0003-1384-3229)
- Bin Xue (ORCID: https://orcid.org/0000-0002-2713-2156)
- Pengfei Wu (ORCID: https://orcid.org/0000-0002-0592-3432)
- Yu Liang (ORCID: https://orcid.org/0009-0001-6729-3763)
- Yu‐Hua Chen
- Ji‐Xin Shi (ORCID: https://orcid.org/0000-0003-2457-1820)
- Libo Jiang (ORCID: https://orcid.org/0009-0000-3409-6934)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Sheng Jing Hospital (CN)
- First Hospital of China Medical University (CN)
- Nanjing Medical University (CN)
- Qiqihar Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1161/jaha.125.043416
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00