Qishen Yiqi Dripping Pills Combined with Exosomes Alleviate Myocardial I/R Injury by Regulating Macrophage Polarization via miRNA-155-5P
Qishen synergistically regulates the miR-155-5p/mTOR/PI3K/Akt signaling axis through ginsenoside components in BMSCs exosomes, promoting macrophage polarization toward M2-type, improving myocardial energy metabolism and attenuating I/R injury, and this protective effect is macrophage-dependent.
Authors
- Wenmin Qin (ORCID: https://orcid.org/0000-0002-1772-0448)
- Liyan Yu (ORCID: https://orcid.org/0000-0002-8861-9806)
- Weizhi Tang
- Feifei Yang (ORCID: https://orcid.org/0009-0002-9551-2596)
- Lin Lin (ORCID: https://orcid.org/0000-0002-7546-4948)
- Meng Wang (ORCID: https://orcid.org/0000-0002-8168-8999)
- Qingwei Zhang (ORCID: https://orcid.org/0000-0002-2008-1755)
- Guixin He (ORCID: https://orcid.org/0009-0009-9041-6467)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Current Stem Cell Research & Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.2174/011574888x408846251007045430
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00