Genetic haplotypes in <i>VWA8, OSBPL6,</i> and <i>ADAMTS9-AS2</i> are associated with immune-related adverse effects in ICI-treated patients with cancer
Novel polymorphisms in <i>VWA8, OSBPL6,</i> and <i>ADAMTS9-AS2</i> may impact immune pathways, promote inflammation, potentiate autoimmune phenotypes, and convey risk of irAE in ICI-treated patients.
Authors
- Hong Mu-Mosley
- Farjana Fattah (ORCID: https://orcid.org/0000-0002-7897-2788)
- Edward K. Wakeland (ORCID: https://orcid.org/0000-0002-7107-0992)
- Igor Puzanov (ORCID: https://orcid.org/0000-0002-9803-3497)
- Yousef Zakharia (ORCID: https://orcid.org/0000-0001-9480-2626)
- Yang Xie (ORCID: https://orcid.org/0000-0002-2190-6966)
- David E. Gerber (ORCID: https://orcid.org/0000-0002-7812-6741)
- Jeffrey A. SoRelle (ORCID: https://orcid.org/0000-0003-2588-6277)
- Mitchell S. von Itzstein (ORCID: https://orcid.org/0000-0003-0530-3169)
- Montaser Shaheen (ORCID: https://orcid.org/0009-0006-1542-2267)
- Benjamin Switzer (ORCID: https://orcid.org/0000-0001-8150-1963)
- Jialiang Liu (ORCID: https://orcid.org/0000-0002-4679-370X)
- Jason Y. Park (ORCID: https://orcid.org/0000-0001-6797-4000)
- Carlos Arana (ORCID: https://orcid.org/0000-0002-3660-1698)
- Gregory A. Daniels
- Prithvi Raj (ORCID: https://orcid.org/0000-0003-4068-4358)
- Chengsong Zhu
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- University of San Diego (US)
- The University of Texas at San Antonio Health Science Center (US)
- Texas Oncology (US)
- UC San Diego Health System (US)
- Mayo Clinic in Florida (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012012
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Melanoma Research Alliance
- University of Texas Southwestern Medical Center
- University of Texas at Austin