Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models
Our data demonstrate that the survival benefits of BTEs in preclinical models of glioma are due to the ability to engage the host immune system in direct killing, induction of immunological memory, and modulation of the TME. These findings provide a deeper insight into the mechanism of BTE actions in GBM.
Authors
- Μαρκέλλα Ζαννίκου (ORCID: https://orcid.org/0000-0003-1452-2056)
- Hinda Najem (ORCID: https://orcid.org/0000-0003-4432-9708)
- Craig Horbinski (ORCID: https://orcid.org/0000-0001-8340-9992)
- Irina V. Balyasnikova (ORCID: https://orcid.org/0000-0002-4664-9441)
- Daniele Procissi (ORCID: https://orcid.org/0000-0001-5350-0170)
- Rebecca Levine (ORCID: https://orcid.org/0000-0002-7067-4719)
- Catalina Lee-Chang (ORCID: https://orcid.org/0000-0002-7675-2124)
- Joseph Duffy (ORCID: https://orcid.org/0000-0002-7895-3966)
- Dolores Hambardzumyan (ORCID: https://orcid.org/0000-0003-1975-4665)
- Jason Miska (ORCID: https://orcid.org/0000-0001-9608-2810)
- Amy B. Heimberger (ORCID: https://orcid.org/0000-0002-9970-8695)
- Lara Leoni
- Dmitri Simberg (ORCID: https://orcid.org/0000-0002-5288-6275)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-6631-7647)
- Aditi Thakur (ORCID: https://orcid.org/0000-0001-5149-8601)
Institutions
- Northwestern University (US)
- Tisch Hospital (US)
- Northwestern Medicine (US)
- Neurological Surgery (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-011714
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00