Expression of hypoxia-inducible factors in clear-cell renal cell carcinoma tumors of adults with and without obstructive sleep apnea
In OSA patients, ccRCC tumors exhibited higher HIF-1α positivity and tumor grades; however, no significant differences in median HIF histoscores, HIF-2α expression, or tumor stage were found. Future studies can use our results to perform formal sample size calculations and elucidate the role of OSA in the pathogenesis of ccRCC.
Authors
- Craig Rogers (ORCID: https://orcid.org/0000-0002-7781-6644)
- Carlos E. Guerra‐Londono (ORCID: https://orcid.org/0000-0002-5227-6047)
- Nilesh Gupta (ORCID: https://orcid.org/0000-0001-6219-2907)
- Syed Johar Raza (ORCID: https://orcid.org/0000-0002-7608-8067)
- Olivia Heppell
Institutions
- Henry Ford Health System (US)
- Wayne State University (US)
- Henry Ford Hospital (US)
Publication Details
- Journal
- Canadian Urological Association Journal
- Published
- 2025-10-27
- DOI
- https://doi.org/10.5489/cuaj.9258
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00