Genetic signatures predict social-cognitive trajectories in ultra-high-risk psychosis: A 24-month longitudinal study
This study provides the first evidence that FABP5 and immunoglobulin-related genetic markers can predict social-cognitive trajectories in individuals at risk for psychosis. These findings support the use of genetic profiling for early identification and highlight new opportunities for personalized preventive strategies in psychiatry.
Authors
- Margaret Williams (ORCID: https://orcid.org/0000-0001-8798-2550)
- Maryam Doborjeh (ORCID: https://orcid.org/0000-0003-4953-0662)
- Alexander Sumich (ORCID: https://orcid.org/0000-0003-4333-8442)
- Tih-Shih Lee (ORCID: https://orcid.org/0000-0002-0788-422X)
- Max Lam (ORCID: https://orcid.org/0000-0002-4256-7844)
- Jie Yin Yee (ORCID: https://orcid.org/0000-0002-4346-445X)
- Edmund Lai (ORCID: https://orcid.org/0000-0001-9159-3718)
- Nikola Kasabov (ORCID: https://orcid.org/0000-0003-4433-7521)
- Sugam Budhraja (ORCID: https://orcid.org/0000-0002-3647-8722)
- Oleg N. Medvedev (ORCID: https://orcid.org/0000-0002-2167-5002)
- Alexander Merkin
- Wilson Wen Bin Goh (ORCID: https://orcid.org/0000-0003-3863-7501)
- Zohreh Doborjeh (ORCID: https://orcid.org/0000-0003-1431-8258)
- Khan Buchwald (ORCID: https://orcid.org/0000-0002-9623-9723)
- Jimmy Lee (ORCID: https://orcid.org/0000-0002-7724-7445)
- Balkaran Singh
Institutions
- Nanyang Technological University (SG)
- University of Konstanz (DE)
- Auckland University of Technology (NZ)
- Duke-NUS Medical School (SG)
- Institute of Mental Health (SG)
- University of Waikato (NZ)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Asian Journal of Psychiatry
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.ajp.2025.104749
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00