AI-based HRCT quantification reveals DLCO and TLC as key determinants of ILD severity in connective tissue diseases
The study presented that DLCO and TLC were predictive for the CTD-ILD severity. Consequently, our findings suggest the performance of PFT, including DLCO for all patients with CTD. In the case of reduced DLCO and TLC, further diagnostics, including HRCT, are necessary.
Authors
- Tobias Hoffmann (ORCID: https://orcid.org/0000-0003-2959-1126)
- Tobias Weise
- Bianca Lassen‐Schmidt (ORCID: https://orcid.org/0000-0001-7888-9928)
- D Renz (ORCID: https://orcid.org/0000-0002-3764-3697)
- Joachim Böttcher
- Felix Güttler (ORCID: https://orcid.org/0000-0002-4414-2188)
- Günter Wolf (ORCID: https://orcid.org/0000-0002-3291-0610)
- Martin Krämer (ORCID: https://orcid.org/0000-0002-0173-9830)
- Ulf Teichgräber (ORCID: https://orcid.org/0000-0002-4048-3938)
- Alexander Pfeil (ORCID: https://orcid.org/0000-0002-2709-6685)
- Luis Benedict Brüheim
Institutions
- Medizinische Hochschule Hannover (DE)
- Fraunhofer Institute for Digital Medicine (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-005963
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung