Application of CTC-derived spheroid for drug screening toward personalized treatment in patients with breast cancer
This study demonstrates that CTC-derived spheroid drug screening provides actionable therapeutic guidance when tissue is unavailable. Combined with hormone receptor and genomic profiling, this liquid biopsy-based platform enables personalized treatment, and dynamic monitoring of resistance in breast cancer.
Authors
- Shin‐Cheh Chen (ORCID: https://orcid.org/0000-0002-0177-0045)
- Yen-Jang Huang
- Shih‐Chiang Huang (ORCID: https://orcid.org/0000-0002-5092-4434)
- Ting-Fang Che
- Syer Choon Lim
- Ying Chang (ORCID: https://orcid.org/0000-0002-8375-6473)
- Hsu‐Huan Chou
- K. J. Lee
- Jia-Yang Chen (ORCID: https://orcid.org/0000-0001-9159-7591)
- Chia-Lung Tsai
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.tranon.2025.102573
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36