Validation of a prognostic nomogram for locally advanced oropharyngeal carcinoma treated with intensity-modulated radiotherapy with/without systemic therapy
Fakhry's model is valid for European OPC patients, and its refinement by including alcohol consumption and smoking-p16 interaction enhances prognostic precision. This improved model may facilitate personalized treatment strategies and clinical trial stratification in this population.
Authors
- Giuseppe Sanguineti (ORCID: https://orcid.org/0000-0001-6937-1406)
- Stefano Calza (ORCID: https://orcid.org/0000-0003-4996-7995)
- P. Bossi
- Renata Gili (ORCID: https://orcid.org/0009-0004-9631-1870)
- Nadia Facchinetti
- E. Orlandi
- Lisa Francesca Licitra (ORCID: https://orcid.org/0000-0003-0623-4118)
- Liliana Belgioia (ORCID: https://orcid.org/0000-0003-0508-6344)
- Marc Oliva (ORCID: https://orcid.org/0000-0001-5352-8130)
- A. Argiris
- Jon Cacicedo (ORCID: https://orcid.org/0000-0001-6195-8034)
- P. Bonomo
- A. Bacigalupo
- M. Maddalo
- P. Franco
- A. Psyrri
- A. García Castaño
Institutions
- Humanitas University (IT)
- Thomas Jefferson University (US)
- University of Milan (IT)
- National and Kapodistrian University of Athens (GR)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Marqués de Valdecilla University Hospital (ES)
- National Center for Oncological Hadrontherapy (IT)
- Sidney Kimmel Cancer Center (US)
- Institut Català d'Oncologia (ES)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Hospital de Cruces (ES)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Piedmont University (US)
- IRCCS Humanitas Research Hospital (IT)
- University of Brescia (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105859
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00