Targeting asparagine potentiates anti-PD-L1 immunotherapy in gastric cancer by enhancing CD8+ T cell anti-tumor response
Our findings indicate that targeting asparagine promotes CD8+ T cell activation and infiltration, thereby remodeling the GC immune microenvironment to enhance host antitumor immunity. The combination of asparagine targeting with anti-PD-L1 therapy elicits potent, synergistic antitumor effects that are demonstrably dependent on CD8+ T cells. This study provides a strong rationale for targeting asparagine metabolism as a novel strategy to improve immunotherapeutic outcomes in GC.
Authors
- Zhan Lu (ORCID: https://orcid.org/0000-0002-3069-079X)
- Xusheng Chang
- M. Ge
- Longfei Wang (ORCID: https://orcid.org/0000-0003-2811-2656)
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-4709-3334)
- Yuan Xu (ORCID: https://orcid.org/0009-0006-3257-4668)
- Kai Yin (ORCID: https://orcid.org/0000-0002-1767-5210)
- Zhaorui Liu (ORCID: https://orcid.org/0000-0002-1589-7987)
- E. Huang (ORCID: https://orcid.org/0000-0003-4263-8195)
- Lü Cui
- Bowen Zheng (ORCID: https://orcid.org/0009-0002-2199-8781)
- Jun Xu
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Wuhan University (CN)
- Changhai Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1626581
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14