Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis
Neutrophil P2Y14R deficiency regulates PKA/AKAP13/RhoA pathway to inhibit neutrophil-platelet aggregate, thereby reducing NET release and venous thrombosis. This indicates that P2Y14R may be a potential therapeutic target for the intervention of VTE using P2Y14R antagonists, including proglumide.
Authors
- Mengze Zhou (ORCID: https://orcid.org/0000-0001-8214-2325)
- Yafei Fang (ORCID: https://orcid.org/0009-0004-2266-2010)
- Yehong Li
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-0861-0204)
- Chunxiao Liu (ORCID: https://orcid.org/0000-0003-4320-7805)
- Min Zhou (ORCID: https://orcid.org/0000-0003-3707-1542)
- Yin Li (ORCID: https://orcid.org/0000-0002-4754-2814)
- Qinghua Hu (ORCID: https://orcid.org/0000-0003-1045-5466)
- Cen Ji
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/eurheartj/ehaf836
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.19