Autosomal dominant tubulointerstitial kidney disease in Chinese patients
This study establishes the first ADTKD cohort in China, revealing distinctive genetic and clinical features, including a high prevalence of UMOD and HNF1B variants. Urine and plasma uromodulin proved to be reliable biomarkers for diagnosing and monitoring ADTKD-UMOD. Incorporating uromodulin testing into clinical practice may improve early diagnosis and management of ADTKD and related kidney diseases.
Authors
- Shu‐Feng Zhou (ORCID: https://orcid.org/0000-0002-7215-707X)
- X Wang (ORCID: https://orcid.org/0000-0002-1584-3225)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-8177-4037)
- Zhuo-ran Song (ORCID: https://orcid.org/0000-0003-1839-2180)
- Jicheng Lv (ORCID: https://orcid.org/0000-0001-9238-9508)
- Bin Wang (ORCID: https://orcid.org/0000-0003-1606-5004)
- Hong Zhang (ORCID: https://orcid.org/0000-0001-9855-4068)
- Yuqing Chen (ORCID: https://orcid.org/0000-0002-5243-5116)
- Li Yang (ORCID: https://orcid.org/0000-0002-2528-5087)
- Mengshi Li (ORCID: https://orcid.org/0000-0003-3398-0183)
- Rui You (ORCID: https://orcid.org/0000-0002-0282-4666)
- Zhiying Liu (ORCID: https://orcid.org/0009-0008-8273-9322)
Institutions
- King University (US)
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Zhongda Hospital Southeast University (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1093/ndt/gfaf229
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00