Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the P

The research received ethics approval from the London School of Hygiene & Tropical Medicine Research Ethics Committee. This study will expand the findings from the FIRST-ABC step-up RCT, providing additional insight from a large representative sample using real-world data. The frequentist and Bayesian approaches will enable a discussion about the advantages and drawbacks of the two strategies. The results will be disseminated to the research and clinical community and made accessible to the public. In addition, the study results will be used in future research, which aims to supplement RCTs with additional evidence from a TTE.

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Publication Details

Journal
BMJ Open
Published
2025-10-01
DOI
https://doi.org/10.1136/bmjopen-2025-105500
Primary Topic
Respiratory Support and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the P

Padmanabhan Ramnarayan, Orlagh Carroll, David A Harrison, Alexina J. Mason et al.
BMJ Open
Respiratory Support and Mechanisms
article

Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the P

Padmanabhan Ramnarayan, Orlagh Carroll, David A Harrison, Alexina J. Mason, Elisa Giallongo, Rebecca Mitting, Sarah E Seaton, Richard Grieve, Dermot Shortt
article en

Abstract

The research received ethics approval from the London School of Hygiene & Tropical Medicine Research Ethics Committee. This study will expand the findings from the FIRST-ABC step-up RCT, providing additional insight from a large representative sample using real-world data. The frequentist and Bayesian approaches will enable a discussion about the advantages and drawbacks of the two strategies. The results will be disseminated to the research and clinical community and made accessible to the public. In addition, the study results will be used in future research, which aims to supplement RCTs with additional evidence from a TTE.

BMJ OpenVol. 15(10)
Imperial College Healthcare NHS Trust (GB), University of Leicester (GB), London School of Hygiene & Tropical Medicine (GB), Intensive Care National Audit & Research Centre (GB), Imperial College London (GB)
National Institute for Health and Care Research, Research for Patient Benefit Programme
Openalex Percentile: Top 55%
Respiratory Support and Mechanisms
DOIOpen Access PDFOpenAlex
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Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the P — Padmanabhan Ramnarayan, Orlagh Carroll, et al. · BMJ Open (2025) | TGRS Research Map | TGRS