Synergistic effects of co-delivery bioactive compounds using polymeric-based nanoparticles for biological activities: recent trends

Abstract The co-delivery of bioactive compounds (BCs) is a potential technique for increasing health benefits beyond those offered by individual nutrients. Presently, the combination of BCs has made perfect sense to boost the nutritional value and health benefits of food products. These combinations integrate the science of whole foods, ancient remedies, and nutraceuticals to improve bioavailability, reduce costs, increase patient compliance, and deliver synergistic therapeutic and biological effects. However, BCs have various drawbacks, including short shelf life due to low chemical stability, poor water solubility, restricted absorption resulting in low bioavailability, quick metabolism and excretion, and vulnerability to breakdown during in vivo digestion. Polymeric-based nanoparticles address this restriction. Polymeric-based nanoparticles systems for co-delivery BCs have demonstrated potential for targeted delivery, controlled release, and improved therapeutic results, such as antioxidant, anti-inflammatory, anti-obesity, anticancer, and cardioprotective properties. This study focuses on polymeric-based nanoparticles for co-delivery of BCs, which are effective carrier for effective targeted and increased biological activity. The study indicated that polymer-based nanoparticles are effective carriers for co-delivering BCs, as they enhance stability, encapsulation efficiency, and therapeutic efficacy and enable controlled, targeted release at specific sites in the human body. Therefore, polymeric-based nanoparticles show promise as innovative nanocarriers for enhancing the stability, protection, controlled release, targeted delivery, and biological activity of co-delivered BCs.