Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer
This study pioneers the application of urinary proteomics in immuno-oncology, providing a non-invasive approach to predict and monitor ICI responsiveness, while offering mechanistic insights into TME dynamics in BTC.
Authors
- Zibo Xu (ORCID: https://orcid.org/0000-0001-8887-9344)
- Jiashuo Chao (ORCID: https://orcid.org/0000-0002-6578-5967)
- Chengpei Zhu (ORCID: https://orcid.org/0000-0002-0291-782X)
- Chengjie Li (ORCID: https://orcid.org/0000-0001-5602-6566)
- Boyu Sun
- Ziyue Huang (ORCID: https://orcid.org/0000-0001-7336-7370)
- Ziyu Xun
- Aiwei Wang (ORCID: https://orcid.org/0000-0001-6373-3170)
- Shuofeng Li (ORCID: https://orcid.org/0000-0003-2747-9501)
- Zhengguang Guo (ORCID: https://orcid.org/0000-0002-5983-7759)
- Haitao Zhao (ORCID: https://orcid.org/0000-0002-3444-8044)
- Nan Zhang (ORCID: https://orcid.org/0000-0001-6518-2501)
- Xiaobo Yang (ORCID: https://orcid.org/0000-0002-8862-4349)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3617-2627)
- Hao Wang (ORCID: https://orcid.org/0000-0001-7252-2674)
- Haidan Sun (ORCID: https://orcid.org/0000-0003-1169-0329)
- Wei Sun (ORCID: https://orcid.org/0000-0002-1493-8249)
- Yunchao Wang (ORCID: https://orcid.org/0000-0001-5705-8519)
- Tan Yang (ORCID: https://orcid.org/0000-0002-7581-4709)
- Han‐Ping Wang (ORCID: https://orcid.org/0000-0002-6012-1774)
- Mingjian Piao (ORCID: https://orcid.org/0009-0005-4981-5942)
- Shanshan Wang (ORCID: https://orcid.org/0000-0001-6214-1405)
- Qiming Feng (ORCID: https://orcid.org/0000-0002-7955-0376)
- Jiongyuan Li
- Kai Liu (ORCID: https://orcid.org/0000-0003-2933-0356)
Institutions
- Capital Medical University (CN)
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhejiang Cancer Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Beijing YouAn Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1136/gutjnl-2025-335513
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01