Reduced endothelial TAK1 impairs vascular integrity in cerebral small vessel disease <i>via</i> the RIPK1-MLKL signalling pathway
Our results demonstrate that TAK1 downregulation in endothelial cells induces RIPK1-MLKL-mediated necroptosis and downregulation of tight junction protein expression. This coordinated mechanism orchestrates cerebrovascular integrity impairment and subsequent cognitive deterioration. This study positions TAK1 as a promising and potential therapeutic target for the prevention and treatment of hypertension-related CSVD.
Authors
- Jing Yang (ORCID: https://orcid.org/0000-0003-2733-8629)
- Kun Zhou (ORCID: https://orcid.org/0000-0003-2955-9804)
- Xiangming Xu
- Yuhua Fan (ORCID: https://orcid.org/0000-0002-9380-2605)
- Chi Xiao (ORCID: https://orcid.org/0000-0002-1522-1928)
- Ming Yi (ORCID: https://orcid.org/0000-0003-1743-9899)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stroke and Vascular Neurology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1136/svn-2025-004469
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00