EASL 2025 indications revisited: phase-specific outcomes with and without nucleos(t)ide analogue therapy in chronic hepatitis B virus infection
NAs therapy was associated with reduced risks of cirrhosis and HCC in HBeAg-positive individuals with high replicative or impending phase transition phenotypes, supporting the expansion of chronic HBV infection treatment criteria.
Authors
- Xiaolong Qi (ORCID: https://orcid.org/0000-0002-3559-5855)
- Shi-Chuan Tang (ORCID: https://orcid.org/0000-0003-4166-7744)
- Yidan Tang (ORCID: https://orcid.org/0000-0003-3150-9873)
- Jianxi Zhang (ORCID: https://orcid.org/0009-0003-2051-3380)
- Zhipeng Lin (ORCID: https://orcid.org/0009-0001-7310-8747)
- Deman Zhang
- Kailing Zhang (ORCID: https://orcid.org/0000-0002-3202-4328)
- Tingfeng Huang (ORCID: https://orcid.org/0000-0002-6440-3664)
- Jie Kong (ORCID: https://orcid.org/0000-0001-7113-9577)
- Zhenwei Chen (ORCID: https://orcid.org/0000-0002-5798-5686)
- Zuxiong Huang (ORCID: https://orcid.org/0000-0003-0994-0384)
- Yeye Wu
- Hongmei Zeng (ORCID: https://orcid.org/0000-0001-7315-245X)
- Qizhu Lin
- Cong Luo (ORCID: https://orcid.org/0000-0002-0879-3127)
- Kongying Lin (ORCID: https://orcid.org/0000-0001-8886-4054)
- Cheng‐Qian Zhong (ORCID: https://orcid.org/0009-0002-1925-4417)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-3096-4981)
- Hongzhi Liu (ORCID: https://orcid.org/0000-0001-7102-6855)
- Rong Tang (ORCID: https://orcid.org/0000-0001-7468-8424)
- YangQuan Chen (ORCID: https://orcid.org/0000-0002-7422-5988)
- Yuehao Shen (ORCID: https://orcid.org/0000-0002-0322-9033)
- Yuntong Li (ORCID: https://orcid.org/0009-0004-1036-1966)
- Jun Fu (ORCID: https://orcid.org/0000-0002-6670-3855)
- Weiping Zhou (ORCID: https://orcid.org/0000-0001-8245-2921)
- Peiling Dong
- Luobin Guo
- Zhenghong Sun
- Peng-Hui You
- Xin Lin
Institutions
- Fujian Medical University (CN)
- Union Hospital (HK)
- Second Military Medical University (CN)
- Longyan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Meizhou City People's Hospital (CN)
- National Cancer Center (US)
- Heze Medical College (CN)
- Zhangzhou Municipal Hospital of Fujian Province (CN)
- Zhongda Hospital Southeast University (CN)
- Zhongshan People's Hospital (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Ningde Normal University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Heze Municipal Hospital (CN)
- Beijing YouAn Hospital (CN)
- Qujiang People's Hospital (CN)
- Shandong First Medical University (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1136/gutjnl-2025-335449
- Citations
- 4
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Science and Technology Projects of Fujian Province
- National Natural Science Foundation of China
- Fujian Provincial Health Commission
- National Key Research and Development Program of China