Mitochondria-targeting near-infrared fluorescent probe for selective detection and imaging of endogenous/exogenous H <sub>2</sub> S in breast cancer models
We developed 152T, a biotinylated near-infrared fluorescent probe with high H<sub>2</sub>S selectivity and mitochondrial targeting. Biotinylation enhances water solubility and tumor retention, while a specific reaction trigger enables distinct H<sub>2</sub>S recognition. Colocalization (0.892 with MitoTracker) and <i>in vivo</i> imaging in MCF-7 tumors-showing rapid signal onset, peak at 150 min, and tumor-specific fluorescence-support its use for real-time H<sub>2</sub>S imaging and cancer diagnosis.
Authors
- Meiqin Luo
- Junning Chen (ORCID: https://orcid.org/0000-0001-7121-0994)
- Yanhua Liu (ORCID: https://orcid.org/0000-0003-1104-284X)
- Yuhan Chen (ORCID: https://orcid.org/0009-0009-8483-2093)
- Zhou Xu (ORCID: https://orcid.org/0000-0003-2977-6841)
- Nan Wu (ORCID: https://orcid.org/0000-0003-1371-5112)
- Huilong Zhu (ORCID: https://orcid.org/0000-0001-7429-2470)
- Tianle Liu (ORCID: https://orcid.org/0000-0003-4995-8781)
Institutions
- Xuzhou Medical College (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05198c
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11