The Molecular Actions of Myricetin and Targeting Cell Signalling Pathways in Cancer Treatment

Numerous biological pathways contribute to the formation and progression of cancer, making it a complex illness. Different molecular participants in various cell signalling cascades must be the focus of effective cancer medications. Myricetin, an isoflavone found in various fruits, vegetables, nuts, berries, and herbs, has been shown to modulate key pathways promoting the survival of cancerous cells. However, its limited bioavailability, pH, and poor water solubility make it difficult to employ clinically. Research is ongoing to develop nano-formulations to enhance bioavailability and absorption, but further research is needed to determine the most effective targeting of the cellular network. Myricetin, a natural flavonoid, has drawn interest because of its anti-inflammatory, anti-oxidant, and anti-cancer properties. Modern molecular methods have illuminated the relationship between dysregulated signal and myricetin. Pathways in the invasion, spread, and development of cancer. However, there is currently limited information available regarding myricetin nano-delivery systems in cancer. In this evaluation, we have included every item in great depth. Considering myricetin-mediated control over many cellular pathways, its consequences for preventing cancer, preclinical and clinical studies and the nano-formulations that are currently on the market for the treatment of different cancers.