STING Promotes Renal Fibrosis of Diabetic Kidney Disease via ID1-Dependent Epithelial-Mesenchymal Transition
Our study provides evidence that STING deficiency relieves renal fibrosis by inhibiting ID1-mediated EMT and that inhibition of STING and ID1 has the potential therapeutic prospects for patients with DKD.
Authors
- Xiaobing Mao (ORCID: https://orcid.org/0009-0008-8166-9748)
- Xia Fang (ORCID: https://orcid.org/0000-0002-5964-8923)
- Mengting Huang (ORCID: https://orcid.org/0000-0001-7583-7970)
- Yang Long (ORCID: https://orcid.org/0000-0003-4668-0681)
- Hongya Wang (ORCID: https://orcid.org/0009-0001-4602-8389)
- Yong Xu (ORCID: https://orcid.org/0000-0002-9534-6252)
- Xiaozhen Tan (ORCID: https://orcid.org/0000-0002-7318-7406)
- Zongzhe Jiang (ORCID: https://orcid.org/0000-0002-1955-181X)
- Yuqing Huang (ORCID: https://orcid.org/0009-0001-4901-4302)
- Yuling Yang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-10-28
- DOI
- https://doi.org/10.4093/dmj.2024.0645
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southwest Medical University