Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
Addition of pioglitazone 30 mg/day to T2DM patients who did not reach the target HbA1c (≤7%) with treatment of dapagliflozin 10 mg/day and metformin over 1,000 mg/day showed effective glucose lowering efficacy without significant hypoglycemia and good tolerability with low prevalence of edema in spite of modest weight gain.
Authors
- Hun‐Sung Kim (ORCID: https://orcid.org/0000-0002-7002-7300)
- Kyong Soo Park (ORCID: https://orcid.org/0000-0003-3597-342X)
- Eui Hyun Kim (ORCID: https://orcid.org/0000-0002-2523-7122)
- Gwanpyo Koh (ORCID: https://orcid.org/0000-0002-6020-2777)
- You‐Cheol Hwang (ORCID: https://orcid.org/0000-0003-4033-7874)
- Jun Hwa Hong (ORCID: https://orcid.org/0000-0002-8693-1038)
- Jong Chul Won (ORCID: https://orcid.org/0000-0002-2219-4083)
- Chang Beom Lee (ORCID: https://orcid.org/0000-0003-4891-834X)
- Hae Jin Kim (ORCID: https://orcid.org/0000-0002-8958-7164)
- Ki Young Ahn (ORCID: https://orcid.org/0000-0002-6527-0277)
- Kyung Ah Han (ORCID: https://orcid.org/0000-0001-6436-1938)
- Eun‐Gyoung Hong (ORCID: https://orcid.org/0000-0003-3390-5706)
- Ho Chan Cho
Institutions
- Seoul National University (KR)
- Eulji University (KR)
- Daegu Fatima Hospital (KR)
- Inje University Sanggye Paik Hospital (KR)
- Hanyang University Guri Hospital (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Jeil Pharmaceutical (South Korea) (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Jeju National University Hospital (KR)
- Keimyung University (KR)
- Ajou University (KR)
- Jeju National University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-10-28
- DOI
- https://doi.org/10.4093/dmj.2024.0696
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hanyang University
- Catholic University of Daegu
- Dongguk University
- Kosin University
- Kyungpook National University
- Seoul National University
- Soonchunhyang University
- Yonsei University
- Hallym University
- Inje University
- Konkuk University
- Korea University
- Catholic University of Korea
- College of Medicine, Koisin University
- Kyungpook National University Hospital
- Seoul Metropolitan Government Seoul National University Boramae Medical Center
- College of Medicine, Seoul National University
- Yonsei University College of Medicine
- College of Medicine, Catholic University of Korea
- Incheon St. Mary's Hospital, Catholic University of Korea