Elucidating the Epigenetic Landscape of Type 2 Diabetes Mellitus: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits
Our study identifies novel genetically regulated CpG sites associated with T2DM risk and highlights OASL as a potential epigenetic regulator of glucose metabolism in α-cells. These findings provide mechanistic insights into the epigenetic architecture of T2DM and suggest potential targets for cross-ethnic biomarker development and therapeutic intervention.
Authors
- Djeane Debora Onthoni (ORCID: https://orcid.org/0000-0001-6990-9456)
- Wayne Huey‐Herng Sheu (ORCID: https://orcid.org/0000-0002-8805-8340)
- Hung‐Yi Chiou (ORCID: https://orcid.org/0000-0002-4545-9697)
- Tzu-Sheng Hsu (ORCID: https://orcid.org/0000-0002-8597-6939)
- Ben‐Yang Liao (ORCID: https://orcid.org/0000-0003-1163-3113)
- Ren‐Hua Chung (ORCID: https://orcid.org/0000-0002-9835-6333)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Chunchao Wang (ORCID: https://orcid.org/0009-0005-3987-1078)
- Chao A. Hsiung
Institutions
- University of Miami (US)
- National Health Research Institutes (TW)
- National Tsing Hua University (TW)
- Dr. John T. Macdonald Foundation (US)
- Taipei Medical University (TW)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-10-28
- DOI
- https://doi.org/10.4093/dmj.2025.0041
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Taiwan Biobank
- University of Pennsylvania
- Human Islet Research Network
- National Health Research Institutes
- National Science and Technology Council