Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii in ICU Environments: Mobile Genetic Elements, Efflux Pumps, and Resistance Mechanism

The ICU environment constitutes an important reservoir for CRAB. The strain I2 harbored key resistance determinants, including efflux pump, and mobile genetic elements, which correlated with its carbapenem-resistant phenotype. Additionally, this strain harbors biofilm-associated genes and disinfectant efflux pump genes, and exhibits moderate biofilm-forming capacity, indicating strong environmental adaptability. The genomic characteristics of strain I2 provide a molecular basis for implementing targeted CRAB infection control strategies in high-risk healthcare settings.