Intraocular Relapse as Initial Manifestation in Pediatric Acute Myeloid Leukemia after Stem Cell Transplant: A Case Report
We present a rare case of intraocular relapse as the first manifestation of acute myeloid leukemia (AML) recurrence in a pediatric patient, occurring 6 months after haploidentical peripheral blood stem cell transplantation (PBSCT). The patient was successfully treated with intravitreal methotrexate (MTX) and systemic reinduction chemotherapy, followed by a second haploidentical PBSCT, achieving sustained complete remission. This case highlights the importance of regular ophthalmic examinations during post-transplant follow-up, as early ocular symptoms can indicate AML recurrence.
Authors
- Yoon Sunwoo (ORCID: https://orcid.org/0000-0001-7444-7823)
- Cheol Min Lee (ORCID: https://orcid.org/0000-0001-8652-4355)
- Yong Hwan Kwon (ORCID: https://orcid.org/0000-0002-0520-9685)
- Chang Ki Yoon (ORCID: https://orcid.org/0000-0003-4637-8044)
- Jung Yoon Choi (ORCID: https://orcid.org/0000-0001-9534-0400)
- Hyoung Jin Kang (ORCID: https://orcid.org/0000-0003-1009-6002)
- Ju‐Yeon Lee (ORCID: https://orcid.org/0000-0003-0653-7223)
- Hyun Jin Park (ORCID: https://orcid.org/0000-0003-4170-0890)
- Bo Kyung Kim (ORCID: https://orcid.org/0000-0003-1151-9636)
- Kyung Taek Hong (ORCID: https://orcid.org/0000-0002-6135-0480)
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Imsang soa hyeoraek jong-yang/Imsang soa hyeol'aeg jong'yang/Clinical pediatric hematology-oncology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.15264/cpho.2025.32.2.41
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00