Extracellular vesicles derived from Filifactor alocis induce interleukin-6 production in osteoblasts via Toll-like receptor 2 signaling
Live and lyophilized F. alocis and F. alocis-derived EVs induce the production of proinflammatory cytokines by osteoblasts, including IL-6. Additionally, the induction of IL-6 by F. alocis-derived EVs involves the activation of TLR2 and PKC. Conclusively, these findings suggest that F. alocis-induced cytokine production by osteoblasts may induce osteoclast differentiation, highlighting its role in the pathogenesis of periodontitis.
Authors
- Tongxin Liu (ORCID: https://orcid.org/0000-0003-2321-8208)
- Hiroyuki Tada (ORCID: https://orcid.org/0000-0002-3049-1096)
- Takashi Nishioka (ORCID: https://orcid.org/0000-0002-1144-3881)
- Eiji Nemoto (ORCID: https://orcid.org/0000-0001-5996-5294)
- Kenji Matsushita (ORCID: https://orcid.org/0000-0003-2402-8633)
- Haruna Yokoi (ORCID: https://orcid.org/0009-0003-5513-791X)
- Kentaro Maruyama
- Y Tsuruta
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106443
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00