SGLT2 inhibitors versus DPP-4 inhibitors and dementia risk in type 2 diabetes: A meta-analysis of cohort studies
SGLT2 inhibitors are associated with a significantly reduced risk of all-cause dementia in T2DM patients compared to DPP-4 inhibitors. While trends favoring SGLT2 inhibitors were observed for dementia subtypes, further long-term studies are needed to confirm these associations.
Authors
- Wei He (ORCID: https://orcid.org/0000-0001-8909-9008)
- Shijie Zhao (ORCID: https://orcid.org/0000-0001-5034-6067)
- Zhaoshuang Zhong (ORCID: https://orcid.org/0000-0001-8507-8891)
- Rongmei Li (ORCID: https://orcid.org/0000-0001-7324-1284)
- Shuyue Xia (ORCID: https://orcid.org/0000-0002-9625-6048)
Institutions
- Shenyang Medical College (CN)
- Central Hospital Affiliated to Shenyang Medical College (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Archives of Gerontology and Geriatrics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.archger.2025.106065
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00