AaeAP2a, a scorpion-derived antimicrobial peptide, combats carbapenem-resistant Acinetobacter baumannii via membrane disruption and triggered metabolic collapse
These findings underscore the potential of AaeAP2a as a promising therapeutic agent for CRAB infections, offering novel strategies for addressing antimicrobial resistance.
Authors
- Huarun Sun
- Ke Ding (ORCID: https://orcid.org/0000-0003-1005-964X)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-0144-6296)
- Xuehan Liu (ORCID: https://orcid.org/0000-0002-8376-5580)
- Liuwei Zhang (ORCID: https://orcid.org/0000-0002-5839-5960)
- Jiyuan Shen
- Weiyu Luo (ORCID: https://orcid.org/0000-0002-7987-2199)
- Jianhe Hu (ORCID: https://orcid.org/0000-0002-6768-0851)
- Bolin Hang
- Lei Wang (ORCID: https://orcid.org/0000-0002-6561-2732)
- Huiying Li (ORCID: https://orcid.org/0000-0001-5633-5270)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0798-667X)
- Bo Wen (ORCID: https://orcid.org/0000-0003-2287-473X)
- Longfei Zhang (ORCID: https://orcid.org/0000-0003-1894-4504)
- Hongyu Gao (ORCID: https://orcid.org/0000-0002-7462-8883)
- Chunling Zhu (ORCID: https://orcid.org/0000-0001-7356-3419)
- Yuliang Wen
- Ruibiao Wang
- Yueyu Bai
Institutions
- Henan University of Science and Technology (CN)
- Henan Institute of Science and Technology (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fmicb.2025.1673333
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00