Serum amyloid A-mediated neuro-inflammation induces hippocampal neuron apoptosis and postoperative cognitive dysfunction in mice
SAA treatment triggers an inflammatory response through the activation of NLRP3, which subsequently causes hippocampal neuron apoptosis and impairs cognitive function in POCD mice. This dysfunction can be reversed by inhibiting NLRP3 with the administration of MCC950.
Authors
- Minghui Tan (ORCID: https://orcid.org/0000-0001-6260-4115)
- Ze Gao
- Yuxuan Wu (ORCID: https://orcid.org/0000-0003-2641-4626)
- Xiaochen Fu (ORCID: https://orcid.org/0000-0001-5554-7474)
- Jing Wang (ORCID: https://orcid.org/0000-0002-4076-9274)
- Zhenbin Cai (ORCID: https://orcid.org/0000-0002-2439-2235)
- Yiwen Xu (ORCID: https://orcid.org/0000-0002-3943-6544)
Institutions
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fphar.2025.1661881
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Medical Research Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province