Integrative multi-omics profiling identifies infiltrative hepatocellular carcinoma as an immunotherapy-resistant subtype with distinct molecular features
Infiltrative HCC is a clinically aggressive and molecularly distinct subtype of advanced HCC. Morphological classification and type IV infiltrative signatures may guide risk stratification and therapeutic decision-making in advanced HCC treated with immunotherapy.
Authors
- Incheon Kang (ORCID: https://orcid.org/0000-0003-4236-5094)
- Gwangil Kim (ORCID: https://orcid.org/0000-0002-4867-9003)
- Ho Yeong Lim (ORCID: https://orcid.org/0000-0001-9325-2300)
- Chansik An (ORCID: https://orcid.org/0000-0002-0484-6658)
- Il Hwan Kim (ORCID: https://orcid.org/0000-0002-4225-002X)
- Sohyun Hwang (ORCID: https://orcid.org/0000-0003-2461-6806)
- Sanghoon Jung (ORCID: https://orcid.org/0000-0003-2473-6453)
- So Jung Kong (ORCID: https://orcid.org/0000-0002-8988-8258)
- Gae Hoon Jo
- Da‐Yeon Lee (ORCID: https://orcid.org/0000-0002-4085-0689)
- Ju‐Seog Lee (ORCID: https://orcid.org/0000-0002-5666-9753)
- Hong Jae Chon (ORCID: https://orcid.org/0000-0002-6979-5812)
- Woo Young Kwon (ORCID: https://orcid.org/0000-0003-0922-9832)
- Beodeul Kang (ORCID: https://orcid.org/0000-0001-5177-8937)
- Haeyoun Kang (ORCID: https://orcid.org/0000-0002-8980-7702)
- Sung-Hwan Lee (ORCID: https://orcid.org/0000-0003-0783-7033)
- Hannah Yang (ORCID: https://orcid.org/0000-0003-2252-7041)
- Youngsoo Kim (ORCID: https://orcid.org/0000-0001-8289-0331)
- Chan Kim (ORCID: https://orcid.org/0000-0001-9780-6155)
- Won Suk Lee (ORCID: https://orcid.org/0000-0003-2753-5294)
- Jung‐Sun Kim (ORCID: https://orcid.org/0000-0003-2263-3274)
- Dong Jun Shin
- Jun Ho Park (ORCID: https://orcid.org/0000-0003-0235-1261)
- Hyeyeong Kim (ORCID: https://orcid.org/0000-0003-1242-7872)
- Seonjeong Woo
- D. Son
Institutions
- Ulsan College (KR)
- The University of Texas MD Anderson Cancer Center (US)
- University of Ulsan (KR)
- Inje University Haeundae Paik Hospital (KR)
- CHA University Bundang Medical Center (KR)
- Ulsan University Hospital (KR)
- CHA University (KR)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3350/cmh.2025.0792
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea