Bacteroides eggerthii ameliorates metabolic dysfunction-associated steatotic liver disease through host–microbe signaling and highlights 2-hydroxyisocaproate as a potential effector
Bacteroides eggerthii ameliorates MASLD via gut-liver axis modulation, including bile acid metabolism and hepatic lipid signaling. These underscore its therapeutic potential and highlight HICA as a novel microbiome-derived metabolite with anti-steatotic activity.
Authors
- Choong Hwan Lee (ORCID: https://orcid.org/0000-0002-2311-185X)
- Jung Woo Eun (ORCID: https://orcid.org/0000-0002-2461-6702)
- Geum Ok Baek (ORCID: https://orcid.org/0000-0003-0124-8844)
- Ji Eun Han (ORCID: https://orcid.org/0000-0001-8208-7709)
- Jae Youn Cheong (ORCID: https://orcid.org/0000-0001-6246-1783)
- Seonghoe Jang (ORCID: https://orcid.org/0000-0001-5018-3480)
- Na Rae Lee (ORCID: https://orcid.org/0000-0001-6155-9906)
- Jongho Choi (ORCID: https://orcid.org/0000-0002-4152-7269)
- Soon Sun Kim (ORCID: https://orcid.org/0000-0002-6862-1896)
- Hojin Jung (ORCID: https://orcid.org/0009-0004-6756-4879)
- Moon Gyeong Yoon
Institutions
- MetaMateria (United States) (US)
- Ajou University (KR)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3350/cmh.2025.0475
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ajou University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea