Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites
PE in G-GEB exerts an RA ameliostatic effect by inhibiting macrophage polarization by regulating cellular glycolysis and by inhibiting the emulsylation modification of histone H3 sites, specifically H3K18la and H3K27la. Therefore, PE is a promising drug candidate for the development of RA treatments.
Authors
- Lianhong Pan (ORCID: https://orcid.org/0000-0002-2788-8455)
- Yijing Pan
- Fan Feng (ORCID: https://orcid.org/0000-0001-8022-5514)
- Dongmei Guo (ORCID: https://orcid.org/0000-0003-4899-844X)
- Mengliang Zhu (ORCID: https://orcid.org/0000-0002-3892-5100)
- Jiaqin Wu
- Chenxi Deng
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-2145-1674)
- Chunli Wang (ORCID: https://orcid.org/0000-0002-5510-2851)
- Kang Xu (ORCID: https://orcid.org/0000-0002-8492-2058)
Institutions
- Hubei University of Chinese Medicine (CN)
- Chongqing Three Gorges University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fphar.2025.1682504
- Primary Topic
- Biological and pharmacological studies of plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province
- Chongqing Municipal Education Commission