FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions
Our study highlights the importance of oxygen tension, ROS homeostasis, and growth factor signaling in shaping the metabolic-epigenetic landscape of hPSCs, with implications for optimizing stem cell culture and differentiation protocols.
Authors
- Petr Fojtík (ORCID: https://orcid.org/0000-0003-0188-0022)
- Petr Skládal (ORCID: https://orcid.org/0000-0002-3868-5725)
- Anton Salykin
- Monika Štětková
- Jana Gregorová (ORCID: https://orcid.org/0009-0009-7226-9459)
- Dáša Bohačiaková (ORCID: https://orcid.org/0000-0002-9538-6668)
- Miroslava Sedláčková
- Pavel Šmak (ORCID: https://orcid.org/0000-0001-8610-5601)
- Deborah Beckerová (ORCID: https://orcid.org/0000-0002-6238-7365)
- Aleš Hampl (ORCID: https://orcid.org/0000-0002-8963-9235)
- Kateřina Holomková (ORCID: https://orcid.org/0000-0002-5133-4946)
- Stjepan Uldrijan (ORCID: https://orcid.org/0000-0001-8316-2539)
- Vladimír Rotrekl (ORCID: https://orcid.org/0000-0002-1298-0849)
- Martin Šenfluk
- Jan Raška (ORCID: https://orcid.org/0000-0001-7957-0214)
- Ondřej Peš (ORCID: https://orcid.org/0000-0002-1325-0418)
Institutions
- Masaryk University (CZ)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fcell.2025.1623814
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00