Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging
The study highlights the gradual loss of the significant directed causal connections between the control and motor networks in different stages of PD. The governing influence of control network over the motor and attentional networks diminishes, leading to the isolation of the somatomotor network. The ability of TPDC-derived features to distinguish prodromal from Parkinson's patients underscores its value for identifying potential biomarkers of disease onset and progression.
Authors
- Hao Ding (ORCID: https://orcid.org/0000-0002-3058-8197)
- Rüdiger Pryss (ORCID: https://orcid.org/0000-0003-1522-785X)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Muthuraman Muthuraman (ORCID: https://orcid.org/0000-0001-6158-2663)
- Tahir Mahmood
- Dumitru Ciolac (ORCID: https://orcid.org/0000-0003-1243-313X)
- Ali Seyfizadeh (ORCID: https://orcid.org/0009-0002-6352-7291)
- Tauqeer Anjum
Institutions
- University of Augsburg (DE)
- University of Würzburg (DE)
- Nicolae Testemițanu State University of Medicine and Pharmacy (MD)
- Universitätsklinikum Würzburg (DE)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fnagi.2025.1698600
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts General Hospital
- Harvard University
- Centre d'Imagerie BioMédicale
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital