White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer’s disease
Pathway-specific polygenic risk for Alzheimer's disease manifests in white matter microstructure by mid- to late adulthood but not in early adulthood, suggesting an age-dependent emergence of genetic effects. dMRI phenotypes may thus serve as intermediate biomarkers for dissecting mechanistic pathways of preclinical Alzheimer's disease vulnerability.
Authors
- J. Harrison (ORCID: https://orcid.org/0000-0002-5775-2524)
- Derek Kenton Jones (ORCID: https://orcid.org/0000-0003-4409-8049)
- Valentina Escott‐Price (ORCID: https://orcid.org/0000-0003-1784-5483)
- Peter Holmans (ORCID: https://orcid.org/0000-0003-0870-9412)
- Evie Stergiakouli (ORCID: https://orcid.org/0000-0003-3586-0927)
- Emily Simmonds (ORCID: https://orcid.org/0000-0001-5691-597X)
- Xavier Caseras (ORCID: https://orcid.org/0000-0002-8490-6891)
- Sonya Foley (ORCID: https://orcid.org/0000-0002-8390-2709)
- Matthew Bracher‐Smith (ORCID: https://orcid.org/0000-0002-0531-6309)
Institutions
- University of Bristol (GB)
- UK Dementia Research Institute (GB)
- Newcastle Hospitals - Campus for Ageing and Vitality (GB)
- MRC Epidemiology Unit (GB)
- Cardiff University (GB)
- Australian Catholic University (AU)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fnins.2025.1638503
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Alzheimer's Society
- University of Bristol
- Dementias Platform UK
- Medical Research Council